Research activities

Catalysis, hydrogenation, metal-organic frameworks, medicinal diagnostics, mass spectrometry

CV

Since 2013: ICT Prague, Drugs and Biomaterials PhD program
2011 - 2013: ICT Prague, Drug Production master degree program
Thesis title: Development of a toolkit for the practical application of enantioselective hydrogenation of cyclic imines on chiral Ru(II) catalysts
Since 2009: Member of the research team at the Department of Organic Technology, ICT Prague
2008 - 2011: ICT Prague, Drug Production and Synthesis bachelor degree program
Thesis title: Screening of lung disease markers and monitoring of their circadian rhythms

Praxe, odborné stáže

8/2011 - 4/2012: Internship at ETH Zürich in cooperation with PSI Villigen (Switzerland)
Topic: Asymmetric hydrogenation catalyzed by metal-organic frameworks

Prizes

2012: Unipetrol Prize at Student Scientific Conference – ICT Prague, Czech Republic

Publications

8. Václavík, J.; Šot, P.; Vilhanová, B.; Pecháček, J.; Kuzma, M.; Kačer, P. Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes. Molecules 2013, 18 (6), 6804–6828.
DOI: 10.3390/molecules18066804
7. Václavík, J.; Pecháček, J.; Vilhanová, B.; Šot, P.; Januščák, J.; Matoušek, V.; Přech, J.; Bártová, S.; Kuzma, M.; Kačer, P. Molecular Structure Effects in the Asymmetric Transfer Hydrogenation of Functionalized Dihydroisoquinolines on (S,S)-[RuCl(η6-p-cymene)TsDPEN]. Catal. Lett. 2013, 143 (6), 555–562.
DOI: 10.1007/s10562-013-0996-4
6. Přech, J.; Václavík, J.; Šot, P.; Pecháček, J.; Vilhanová, B.; Januščák, J.; Syslová, K.; Pažout, R.; Maixner, J.; Zápal, J.; Kuzma, M.; Kačer, P. Asymmetric transfer hydrogenation of 1-phenyl dihydroisoquinolines using Ru(II) diamine catalysts.Catal. Commun. 2013, 36, 67–70.
DOI: 10.1016/j.catcom.2013.03.004
5. Kuzma, M.; Václavík, J.; Novák, P.; Přech, J.; Januščák, J.; Červený, J.; Pecháček, J.; Šot, P.; Vilhanová, B.; Matoušek, V.; Goncharova, I. I.; Urbanová, M.; Kačer, P. New insight into the role of a base in the mechanism of imine transfer hydrogenation on a Ru(II) half-sandwich complex. Dalton Trans. 2013, 42 (14), 5174–5182.
DOI: 10.1039/C3DT32733G
4. Přech, J.; Matoušek, V.; Václavík, J.; Pecháček, J.; Syslová, K.; Šot, P.; Januščák, J.; Vilhanová, B.; Kuzma, M.; Kačer, P. Determination of Enantiomeric Composition of Substituted Tetrahydroisoquinolines Based on Derivatization with Menthyl Chloroformate. Am. J. Anal. Chem. 2013, 4 (3), 125–133.
DOI: 10.4236/ajac.2013.43017
3. Pecháček, J.; Václavík, J.; Přech, J.; Šot, P.; Januščák, J.; Vilhanová, B.; Vavřík, J.; Kuzma, M.; Kačer, P. Asymmetric Transfer Hydrogenation of Imines Catalyzed by a Noyori-Type Ru(II) Complex – A Parametric Study. Tetrahedron: Asymmetry 2013, 24 (4), 233–239.
DOI: 10.1016/j.tetasy.2013.01.010
2. Vilhanová, B.; Matoušek, V.; Václavík, J.; Syslová, K.; Přech, J.; Pecháček, J.; Šot, P.; Januščák, J.; Toman, J.; Zápal, J.; Kuzma, M.; Kačer, P. Two optimized synthetic pathways toward a chiral precursor of
Mivacurium chloride and other skeletal muscle relaxants Tetrahedron: Asymmetry 2013, 24 (1), 50–55.
DOI: 10.1016/j.tetasy.2012.11.012
1. Syslová, K.; Kačer, P.; Vilhanová, B.; Kuzma, M.; Lipovová, P.; Fenclová, Z.; Lebedová, J.; Pelclová, D. Determination of cysteinyl leukotrienes in exhaled breath condensate: Method combining immunoseparation with LC–ESI-MS/MS. J. Chrom. B 2011, 879, 2220–2228.
DOI: 10.1016/j.jchromb.2011.06.004

Conferences

2012: Student scientific conference (talk) – ICT Prague, Czech Republic
44th Symposium on Catalysis (poster) – Prague, Czech Republic
SCS Fall Meeting (poster) – ETH Zürich, Switzerland
2010: Student scientific conference (talk) – ICT Prague, Czech Republic

Courses

2010: 11th Shool of mass spectrometry,
20.-24.9., Pec pod Sněžkou, Czech Republic

Current research project