Research activities

Catalysis, Anti-Markovnikov alkyne hydration, organic synthesis


Since 2011: Member of the research team at the Department of Organic Technology, ICT Prague
Since 2011: ICT Prague, Organic Technology PhD program
2009 - 2011: ICT Prague, Drug Production master degree program
Thesis title: Synthesis of octanenitrile
2006 - 2009: ICT Prague, Drug Production and Synthesis bachelor degree program
Thesis title: A general one-step synthesis of alkynes from enolisable carbonyl compounds


Since 9/2011: Zentiva Group, a.s.
PhD student: Synthesis development, research group of Assoc. Prof. Stanislav Rádl
3/2008 - 10/2010: The Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
Lab assitant: Organic synthesis, research group of Dr. Lyapkalo


3. Pecháček, J.; Václavík, J.; Přech, J.; Šot, P.; Januščák, J.; Vilhanová, B.; Vavřík, J.; Kuzma, M.; Kačer, P. Asymmetric Transfer Hydrogenation of Imines Catalyzed by a Noyori-Type Ru(II) Complex – A Parametric Study. Tetrahedron: Asymmetry 2013, 24 (4), 233–239.
DOI: 10.1016/j.tetasy.2013.01.010
2. Kunetskiy, R. A.; Polyakova, S. M.; Vavřík, J.; Císařová, I.; Saame, J.; Nerut, E. R.; Koppel, I.; Koppel, I. A.; Kütt, A.; Leito, I.; Lyapkalo, I. A New Class of Organosuperbases, N-Alkyl- and N-Aryl-1,3-dialkyl-4,5-dimethylimidazol-2-ylidene Amines: Synthesis, Structure, pKBH+ Measurements, and Properties. Chem. Eur. J. 2012, 18, 3621-3630.
DOI: 10.1002/chem.201102249
1. Lyapkalo, L.; Vogel, I.; Boltukhina, E.; Vavřík, J. A General One-Step Synthesis of Alkynes from Enolisable Carbonyl Compounds. Synlett 2009, 4, 558-561.
DOI: 10.1055/s-0028-1087919


2012: 44th Symposium on Catalysis (poster) – Prague, Czech Republic

Current research project

The research is focused on the proposal and subsequent preparation of phoshpine ligands suitable for anti-Markovnikov addition of water to terminal alkynes. Ruthenium catalysts will be prepared from the ligands obtained and applied to reactions with a broad spectrum of alkyne substrates. Possible immobilization of these catalysts on suitable polymer supports will also be investigated.